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Lower thresholds likely exclude individuals without pauses in medication, whereas higher thresholds more likely relate to the actual dosage that individuals receive (i.e., those with no pauses but receiving low-to-intermediate doses are excluded with these thresholds)
10.3109/10408444.2015.1074159 Crit
In the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) study, the incidence of cardiovascular disease was lower when liraglutide was used in patients with type 2 diabetes [15]
15 If your formulation is more stable and does not require cold-chain logistics (which currently costs a fortune in packaging and shipping), you have a compelling case for reimbursement even at a premium over generic competitors
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